The Effectiveness of Checkpoint Inhibitor Combinations and Administration Timing Can Be Measured by Granzyme B PET Imaging Benjamin M. Larimer, Emily Bloch, Sarah Nesti, Emily E. Austin, Eric Wehrenberg-Klee, Genevieve Boland and Umar Mahmood 2019 February ABSTRACT Purpose: The lack of a timely and reliable measure of response to cancer immunotherapy has confounded understanding of mechanisms of resistance [...]

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer Giorgia Zadra,a,b,1 Caroline F. Ribeiro,a Paolo Chetta,a,c Yeung Ho,d Stefano Cacciatore,e,f Xueliang Gao,gSudeepa Syamala,a Clyde Bango,a Cornelia Photopoulos,a Ying Huang,a Svitlana Tyekucheva,h,iDebora C. Bastos,j Jeremy Tchaicha,k,2 Brian Lawney,l Takuma Uo,m Laura D’Anello,a Alfredo Csibi,k,3Radha Kalekar,a Benjamin Larimer,n Leigh Ellis,a,b,o Lisa M. Butler,p,q,r Colm Morrissey,m Karen McGovern,k,4Vito J. Palombella,k,5 Jeffery L. Kutok,k Umar Mahmood,n Silvano Bosari,s,t Julian Adams,k,6 Stephane Peluso,k,7Scott M. Dehm,d,u,v Stephen R. Plymate,m and Massimo [...]

Reporter Genes for PET Imaging of CAR T Cells Offers Insight into Adoptive Cell Transfer Benjamin M. Larimer 2018 December Immunotherapy has drastically altered cancer treatment over the past decade. Several strategies have emerged to successfully harness the immune system as a therapeutic instrument. [...]

Specific 18 F-FDHT Accumulation in Human Prostate Cancer Xenograft Murine Models Is Facilitated by Prebinding to Sex Hormone–Binding Globulin Benjamin M. Larimer1, Frank Dubois1, Emily Bloch1, Sarah Nesti1, Michael Placzek1, Giorgia Zadra2,3, Jacob M. Hooker1, Massimo Loda2,3 and Umar Mahmood1 2018 October ABSTRACT Tremendous efforts are currently dedicated to the development [...]

Phage Display Selection, In Vitro Characterization, and Correlative PET Imaging of a Novel HER3 Peptide Benjamin M. Larimer, Nicholas Phelan, Eric Wehrenberg-Klee, Umar Mahmood 2018 April ABSTRACT Purpose HER3 (ERBB3) is a receptor tyrosine kinase that is implicated in treatment resistance across multiple cancers, including those [...]

Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response Benjamin M. Larimer, Eric Wehrenberg-Klee, Frank Dubois, Anila Mehta, Taylor Kalomeris, Keith Flaherty, Genevieve Boland and Umar Mahmood ABSTRACT While cancer immunotherapy can produce dramatic responses, only a minority of patients respond to treatment. Reliable response biomarkers are needed to identify responders, and conventional imaging modalities have not proved [...]

Quantitative CD3 PET Imaging Predicts Tumor Growth Response to Anti-CTLA-4 Therapy Benjamin M. Larimer, Eric Wehrenberg-Klee, Alexander Caraballo and Umar Mahmood 2016 October ABSTRACT Immune checkpoint inhibitors have made rapid advances, resulting in multiple Food and Drug Administration–approved therapeutics that have markedly improved survival. However, these [...]

Differential Receptor Tyrosine Kinase PET Imaging for Therapeutic Guidance Eric Wehrenberg-Klee*,1, N. Selcan Turker*,1, Pedram Heidari1,Benjamin Larimer1, Dejan Juric2, José Baselga3, Maurizio Scaltriti3 andUmar Mahmood1 2016 September ABSTRACT Inhibitors of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway hold promise for the treatment of breast cancer, but [...]

Multiple Bacteriophage Selection Strategies for Improved Affinity of a Peptide Targeting ERBB2 Benjamin M. Larimer, Jeanne M. Quinn, Kevin Kramer, Andrey Komissarov, Susan L. Deutscher 2015 December ABSTRACT Due to the heterogeneity of ERBB2-expression between tumors and over the course of treatment, a non-invasive molecular [...]

Affinity Maturation of an ERBB2-Targeted SPECT Imaging Peptide by In Vivo Phage Display Benjamin M. Larimer, William D. Thomas, George P. Smith, Susan L. Deutscher 2014 August ABSTRACT Purpose The goal of this study was to improve the pharmacokinetic properties and specificity of an ERBB2-targeted peptide for [...]